The only active ingredient in Estrovera is Siberian rhubarb extract
(ERr731).
This extract is believed to have the potential to reduce hot flashes,
night sweats, and other menopause symptoms. However, the specific effects of
this ingredient on hormone levels and symptom relief are mixed. Estrovera’s
ingredient has been around since the 90’s so there is a reasonable amount of studies
although 2 in particular are the most cited in it's favor.
This first was a placebo-controlled trial published in Menopause in 2006.
This trial investigated the efficacy and safety of ERr731 in perimenopausal
women with severe hot flashes. The study involved a 12-week treatment period,
and the results showed significant improvements in menopausal symptoms, as
measured by the Menopause Rating Scale. [1]
The second most commonly cited study published in 2008 aimed to demonstrate the efficacy of
ERr731 for menopausal issues over a longer period (6 months). The researchers
enrolled 363 menopausal women with symptoms and administered ERr731 for six
months. The results revealed a significant decrease in the MRS total scores.
This mostly effected hot flashes and mood, but other scores improved as well.
As such it is reasonable to make claims that estrovera should have some
improvement to menopausal symptoms. [2]
The catch is that in the real world it seems to only really be effective
for about 50% of people, and several other trials showed that the Siberian rhubarb
in estrovera was not effective.
However,
because it’s such a small ingredient, it is perfect for combined supplements that
use other natural ingredients for menopause symptoms.
Estrovera is primarily sold through their main site and amazon, and the usual
retail price for Estrovera is around $34.95 per bottle. Which
considering Estroven which is exactly the same costs $19.95, we would suggest that
instead.
References
1 - https://pubmed.ncbi.nlm.nih.gov/16894335/
2 - https://pubmed.ncbi.nlm.nih.gov/19043936/
3 - https://pubmed.ncbi.nlm.nih.gov/19161045/
4 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409715/