10mg Melatonin – Melatonin is fast acting and can start to make people sleepy within as little as 30 mins. It is the natural hormone that your body produces to let you know it's time to go to sleep. As we already covered in the intro, melatonin is well documented as a sleep aid, it’s known for not forming a habit by comparison to heavier alternatives and is often a first port of call as a recommendation by practitioners. The catch is as we mentioned this is a very high dose [1] and is not ideal for first time users of the supplement.
200mg L Theanine – L Theanine has been shown in multiple studies to improve sleep quality at doses of 200mg [5] so this is a solid inclusion for Sleep3, the same studies however have often shown that it does not improve the speed at which people fall asleep despite common claims around the amino acid.
50mg blend of valerian root, lavender, chamomile and lemon balm – This is where we have some sleep3 complaints, as we’ve already mentioned valerian root requires 200mg [3] and lavender simply doesn’t work orally [4]. Valerian’s low dosage is a particular shame as it is one of the more well backed natural sleep aids for both increasing speed of getting to sleep and sleep quality. It’s also been shown to be quite good for stress and anxiety, a common cause of restlessness to begin with.
Chamomile can work through oral supplementation, but in far higher doses (grams not milligrams, so 100X more) and typically works better when consumed as a tea. [6] Like valerian it does also seem to have some benefit for stress.
And as for Lemon Balm, we’re in a similar boat as chamomile, and too make matters worse the studies on whether it works at all are very mixed. [7] There’s more evidence for it as a stress aid than as a sleep aid, although that isn’t to say that there’s none at all. Either way the dosage would need to be over 200mg, which is far more than can possibly be included in the 4 ingredient 50mg blend.
Working with trying to keep everything in a single pill, Sleep3 would’ve been far better off looking to include GABA or 5htp, which can be dosed in just 200 or 100mg respectively.
Sleep3 will be safe for most adults, although people should take care with melatonin as it can cuase daytime drowsiness for some.
Sleep3 is available on amazon.com
Do not take more than one sleep3 tablet a day and we would not recommend taking it more than an hour before you plan to go to sleep.
Resources:
1 - https://www.nccih.nih.gov/health/melatonin-what-you-need-to-know
2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017334/
3 - https://ods.od.nih.gov/factsheets/Valerian-HealthProfessional/
4 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505755/
5 - https://pubmed.ncbi.nlm.nih.gov/25759004/
6 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/
7 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245564/